Tetrahedron, Volume 76, Issue 41 , 09/10/2020

A cyclic lipodepsipeptide, a spirolactone, and a chromanone from the marine fungus Verruculina enalia (Kohlm.) Kohlm. & Volkm.-Kohlm. BCC 22226

Taridaporn Bunyapaiboonsri, Seangaroon Yoiprommarat, Rinrada Suntivich, Sita Preedanon, Somjit Komwijit, Thapong Teerawatananond, Jariya Sakayaroj

Abstract

A cyclic lipodepsipeptide, verruculin, a rosigenin and an aposphaerin analogues, verruculinone and 7-O-methylaposphaerin C, together with six known compounds were isolated from the marine fungus Verruculina enalia BCC 22226. The structures of these compounds were elucidated by extensive spectroscopic analysis. The absolute configuration of verruculin was determined by Marfey's method, and the relative configuration of verruculinone was obtained by X-ray crystallography. Verruculin showed weak antituberculosis and antibacterial activities, while verruculinone displayed cytotoxicity against cancer cell (MCF-7 and NCI–H187) and Vero cell lines.

Document Type

Article

Source Type

Journal

Keywords

Antibacterial activityCyclic lipodepsipeptideCytotoxic activitySpirolactoneVerruculina enalia

ASJC Subject Area

Chemistry : Organic ChemistryPharmacology, Toxicology and Pharmaceutics : Drug DiscoveryBiochemistry, Genetics and Molecular Biology : Biochemistry

Funding Agency

National Science and Technology Development Agency

Access to Document

DOI : 10.1016/j.tet.2020.131497
Link to scopus


14

Citations (Scopus)

Bibliography


Bunyapaiboonsri, T., Yoiprommarat, S., Suntivich, R., Preedanon, S., Komwijit, S., Teerawatananond, T., & Sakayaroj, J. (2020). A cyclic lipodepsipeptide, a spirolactone, and a chromanone from the marine fungus Verruculina enalia (Kohlm.) Kohlm. & Volkm.-Kohlm. BCC 22226. Tetrahedron, 76(41) doi:10.1016/j.tet.2020.131497

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