Tetrahedron, Volume 74, Issue 39, Pages 5659-5664 , 27/09/2018

Blennolide derivatives from the soil-derived fungus Trichoderma asperellum PSU-PSF14

Athip Maha, Patima Phainuphong, Vatcharin Rukachaisirikul, Saowanit Saithong, Souwalak Phongpaichit, Sarinya Hadsadee, Siriporn Jungsuttiwong, Sita Preedanon, Jariya Sakayaroj

Abstract

Three new blennolide derivatives, blennolides L-N (1–3), together with five known metabolites were isolated from the soil-derived fungus Trichoderma asperellum PSU-PSF14. Their structures were determined by analysis of spectroscopic data. Their relative configurations were determined by analysis of NOEDIFF data and confirmed by X-ray crystallography for compound 1 whereas the absolute configurations were established by means of experimental and calculated TDDFT ECD data. Compound 1 displayed antifungal activity against Cryptococcus neoformans ATCC90112 and ATCC90113 flucytosine-resistant with the MIC values of 128 and 64 μg/mL, respectively, and was inactive against noncancerous Vero cell lines.

Document Type

Article

Source Type

Journal

Keywords

Antifungal activityBlennolide derivativesCytotoxic activitySoil-derived fungusTrichoderma asperellum

ASJC Subject Area

Chemistry : Organic ChemistryPharmacology, Toxicology and Pharmaceutics : Drug DiscoveryBiochemistry, Genetics and Molecular Biology : Biochemistry

Funding Agency

National Science and Technology Development Agency

Access to Document

DOI : 10.1016/j.tet.2018.07.041
Link to scopus


6

Citations (Scopus)

Bibliography


Maha, A., Phainuphong, P., Rukachaisirikul, V., Saithong, S., Phongpaichit, S., Hadsadee, S., Jungsuttiwong, S., ... Sakayaroj, J. (2018). Blennolide derivatives from the soil-derived fungus Trichoderma asperellum PSU-PSF14. Tetrahedron, 74(39) 5659-5664. doi:10.1016/j.tet.2018.07.041

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