Abstract

There has been growing evidence showing the widespread of airborne microplastics (AMPs) in many regions of the world, raising concerns about their impact on human health. This review aimed to consolidate recent literature on AMPs regarding their physical and chemical characteristics, deposition in the human respiratory tract, translocation, occurrence from human studies, and toxic effects determined in vitro and in vivo. The physical characteristics influence interactions with cell membranes, cellular internalization, accumulation, and cytotoxicity resulting from cell membrane damage and oxidative stress. In addition, prolonged exposure to AMP-associated toxic chemicals might lead to significant health effects. Most toxicological assessments of AMPs in vitro and in vivo have demonstrated that oxidative stress and inflammation are major mechanisms of action for their toxic effects. Elevated reactive oxygen species production could lead to mitochondrial dysfunction, inflammatory responses, and subsequent apoptosis in experimental models. To date, there has been some evidence suggesting exposure in humans. However, the data are still insufficient, and adverse human health effects need to be investigated. Future research on the existence, exposure, and health effects of AMPs is required for developing preventive and mitigation measures to protect human health.