Abstract

Background/Objectives: Inflammatory skin disorders such as dermatitis, psoriasis, and acne that affect patients’ quality of life and health require safe and effective active delivery systems. In Thai traditional medicine, Curcuma aromatica has long been used to treat skin disorders and for cosmetic skin care. However, the research is scarce. This study aimed to develop and evaluate a novel anti-inflammatory and anti-acne hydrogel patch containing C. aromatica extract. Methods: The hydrogel patch formulations were prepared, and their mechanical properties, in vitro release, skin permeation, in vitro anti-inflammatory and anti-acne activities, and physicochemical properties were studied. Results: The C. aromatica hydrogel patch (CA2 formulation) made from carrageenan, locust bean gum, PVP-K30, and C. aromatica extract displayed excellent physical appearance and mechanical properties; it was smooth, durable, and flexible. Curcumin, an active ingredient, was released from the C. aromatica hydrogel patch within the first 30 min (19.07 ± 1.14%), reaching its peak at 12 h (50.40 ± 3.94%), with sustained permeation of 38.18 ± 0.45% at 24 h. Data from the drug release and permeation study better fit Higuchi’s kinetic model. Additionally, the CA2 hydrogel patch demonstrated anti-inflammatory activity, with an IC<inf>50</inf> value of 19.85 ± 0.82 μg/mL, and was also effective against Cutibacterium acne, with an inhibition zone of 12.70 ± 2.10 mm. Conclusions: The developed C. aromatica hydrogel patch not only showed great physicochemical properties but also had anti-inflammatory and anti-acne activities; it prolonged curcumin release, enabling delivery of the drug to treat skin inflammation disorders. The CA hydrogel patch is suitable for use as an anti-acne facial mask and for inflamed skin areas; however, it should be further evaluated in clinical trials.